چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | علوم پزشکی بابل |
| Objectives: To determine whether granulocyte colony-stimulating factor (G-CSF) could reverse liver damage in the model of acute liver injury induced by carbon tetrachloride (CCL4) Design: Prospective, using experimental animal model of acute and chronic liver injury Setting: Babol University of Medical Sciences, Babol, Iran Subjects: We established an animal model of liver damage by administration of CCL4 (1 ml/kg, IP). Two hours later the animals were treated with G-CSF (100 μg /kg body weight, IP). On the 28th day, rats were scarified.Malondialdehyde(MDA) was determined using diagnostic kits following recommendations of manufacturer of the kits. Serial 5 μm thick liver sections were stained with haematoxylin-eosin and Masson,s trichrome and examined. Main Outcome Measures: Reduction in serum albumin and total protein levels (1.24 ± 0.16 and 3.22 ± 0.21 g/dl, respectively) were 2.58 ± 0.19 and 6.82 ± 0.30 g/dl, respectively reversed by G-CSF treatment. Results: CCL4-induced increase in serum AST, ALT, and ALP activities and MDA and hydroxyproline levels were significantlysuppressedbyG-CSFtreatment. Conclusions: G-CSF stimulates liver repair and may be clinically beneficialinrestoringliverdamage.Therewasapositive correlation (p < 0.05) between histopathological and biochemical parameters. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سهراب حلال خور | ششم |
| حسن طاهری | پنجم |
| فریده فیضی | سوم |
| دردی قوجق | اول |
| هادی پارسیان | چهارم |
| رویا عباسی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|
